74393 DATASHEET PDF

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Anti-Lamin B1 antibody (ab74393)

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Datasheet(PDF) – Harris Corporation

Your name Your email. Send me a copy of this email. I agree to the terms and conditions. Cell Biology Apoptosis Nucleus Lamins. Datasheet References Protocols Overview.

Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6. Lamins datashest components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.

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B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Western blot – Anti-Lamin B1 antibody ab Submit a review Submit fatasheet question. Get resources and offers direct to your inbox Sign up. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Use at an assay dependent concentration.

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