Within inflammatory complications sarcoidal granulomatous reactions have been described. . Granuloma sarcoideo y granuloma a cuerpo extraño; pp. 9– English Translation, Synonyms, Definitions and Usage Examples of Spanish Word ‘granuloma sarcoideo’. O granuloma sarcoídeo é granuloma imunológico, constituído pelo arranjo concêntrico de células epitelióides, que consistem em histiócitos modificados pela.

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Numerous infectious, inflammatory and neoplastic complications secondary to tattoo placement have been reported in the literature. Within inflammatory complications sarcoidal granulomatous reactions have been described. We report two cases, a year-old woman with yellowish infiltrated plaques on bilateral ciliary region, 16 years after the placement of a permanent tattoo in the eyebrows, and a year-old tattoo artist who developed orange papules on 3 sarcoidso his tattoos.

Histopathology in both cases confirmed diagnosis of sarcoidal granulomatous reaction due to tattoo pigment. Facial tattoos as a permanent or semi-permanent makeup are nowadays increasingly popular cosmetic procedures; nevertheless, reactions described in the literature secondary to this procedure are less frequent than those reported with decorative body tattoos. These reactions can sometimes be the only sign of cutaneous or underlying systemic sarcoidosis, so in these patients it is appropriate to conduct additional studies and regular follow-up.

A year-old female patient reported a 2-year history of itchy persistent lesions on the eyebrows. She had a permanent makeup cosmetic tattoo 16 years before the onset of lesions Figure 1.

Histopathological examination of one of the lesions showed thick dermis yranuloma lymphocytic infiltrates around epithelioid granulomas involving the entire dermis, with presence of black pigment in the central portion Figure 2.

Noninfectious granulomas: sarcoidosis

She was diagnosed with sarcoidal granulomatous reaction secondary to tattoo. Complementary studies included blood count, liver function tests, chest radiography and tuberculin skin test, all were within normal limits. Patient received two intralesional therapies with triamcinolone acetonide 0.


She denied respiratory or ocular symptoms. Physical examination revealed well-defined yellowish-brown infiltrated plaques located in the inner third of the eyebrows.

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Dense granulomatous infiltrate involving the entire dermis with presence of pigmented granules in the papillary dermis. Epithelioid granulomas surrounded by lymphocytic infiltrates with black pigment in the central portion. The second case was a year-old man, tattoo artist, who reported the onset of painful lesions on 3 tattoos made one year and a half earlier Figure 3. Histopathology revealed a sarcoidal granulomatous reaction Figure 4. Physical examination showed areas of tattoos on his forearms, right thigh and foot with numerous salmon-colored papules and plaques with discrete scaling at the periphery.

Epithelioid granulomas with central black pigment involving the entire dermis with mild inflammatory infiltrate. Tattoos were traditional symbols among many cultures and continue to be a common practice.

Tattoos can cause numerous cutaneous and systemic diseases. Considering inflammatory complications secondary to tattoos, hypersensitivity reactions to pigments injected into the skin are relatively frequent. The first case of sarcoidal tattoo reaction tranuloma described in ; 2 since then, there sarcoudeo been numerous reports, including those associated with cosmetic tattoos in women who underwent permanent makeup, as is the case of our first patient. Pathogenic mechanisms leading to granulomatous immune response in an affected area of skin are still unknown.

Depending on the etiology, the factor that triggers the formation of granulomas may have autoimmune or infectious origin. Lo Schiavo et al.

Sarcoidal granulomatous reaction due to tattoos: report of two cases

Histopathologic evidence of sarcoidal granulomatous reaction in the presence of exogenous material pigment should not be considered as a criterion to exclude the diagnosis of cutaneous sarcoidosis. It is postulated that presence of exogenous material may act as antigenic stimulus that can induce persistent granulomatous inflammatory sarcoireo leading to development of sarcoidosis in genetically susceptible individuals.

Sarcoidal reactions associated with tattoos are mainly treated with high- or ultra-high-potency topical or intralesional steroids that we offered for both patients. There are also reports of treatment of these reactions with allopurinol, a xanthine oxidase inhibitor, which reduces the production of free radicals involved in granulomas formation. Tattoos either for cosmetic or artistic purposes are an increasing practice worldwide, with a concomitant rise in tattoo-associated complications.


For this reason, dermatologists and pathologists should be aware of these complications to approach an accurate diagnosis and therapy. National Center for Biotechnology InformationU. Journal List An Bras Dermatol v. Find articles by Martha Cecilia Valbuena. Find articles by Victoria Eugenia Franco. Author information Article notes Copyright and License information Disclaimer. Received Mar 31; Accepted Nov This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.

Abstract Numerous infectious, inflammatory and neoplastic complications secondary to tattoo placement have been reported in the literature.

Grauloma in a sarckideo window. Footnotes Conflict of Interests: Spontaneous resolution of a delayed granulomatous reaction to cosmetic tattoo. Sarcoid granuloma on black tattoo. J Am Acad Dermatol. Juhas E, English JC 3rd.

sarcoixeo J Pediatr Adolesc Gynecol. Tattoo reactions–an epidemic on the surge: Indian J Dermatol Venereol Leprol. Granulomatous dysimmune reactions sarcoidosis, granuloma annulare, and others on differently injured skin areas.

Development of sarcoidosis in cosmetic tattoos. Granulomatous reactions to permanent cosmetic tattoos successfully treated with topical steroids and allopurinol. Clinical applications of non-antimicrobial tetracyclines in dermatology. Doherty CB, Rosen T. Evidence-Based Therapy for Cutaneous Sarcoidosis. Support Center Support Center. Please review our privacy policy.

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