Hydrotropic Solubilization. Priyanka Arjaria1, Manoj Goyal2, Suman Jain3. 1Shri Ram College of pharmacy,Banmore,Morena, India, 2IPS College of pharmacy. Purpose. This study examines the mechanism of hydrotropic solubilization using the riboflavin-nicotinamide system. The most commonly proposed mechanism. On the other hand, planarity of the hydrophobic part has been emphasized as an important factor in the mechanism of hydrotropic solubilization. Solute consists.
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Hydrotropic solubilization of poorly water-soluble drugs.
Lornoxicam is a selective cyclooxygenase-1 and cyclooxygenase-2 inhibitor that exhibits anti-inflammatory, analgesic, and antipyretic activities. It is used in osteoarthritis and rheumatoid arthritis; and in treatment of postoperative pain and primary dysmenorrhoea. Lornoxicam is completely insoluble in water but soluble in alkaline solutions. The solubility hydrotroppic lornoxicam in distilled water considerably increased with the addition of a hydrotropic agent.
The analysis of tablets indicated good correlation between the amounts estimated and label claim. The percentage recovery was found to be Thus the proposed method is new, simple, environmentally friendly, accurate, and cost effective and can hydrtropic successfully employed in routine analysis of lornoxicam in tablets.
Various techniques have been employed to enhance the aqueous solubility of poorly water-soluble drugs. Hydrotropic solubilization is one such method [ 1 ]. Hydrotropes are a class of chemical compounds which affect an increased aqueous solubility by several folds to certain solutes which are sparingly soluble in water under normal conditions. Therapeutic efficacy of a drug depends upon its bioavailability and ultimately its solubility to achieve a desired concentration in systemic circulation.
Because of their low aqueous solubility and high permeability, dissolution from delivery systems forms the rate limiting step in their absorption and systemic bioavailability [ 23 ]. Increasing the aqueous solubility of insoluble and slightly soluble drugs is of major importance and hydrotropy can be considered as a potential and industrially attractive technique because of easy recovery of dissolved solute and possible reuse of hydrotrope solutions.
Hydrotropes such as sodium benzoate, sodium salicylate, niacinamide, sodium hydroxide, sodium citrate, PEGpolyvinyl alcohol, and urea have been employed to enhance the aqueous solubility of poorly water-soluble drugs [ 3 ].
Lornoxicam, an oxicam derivative, is a nonsteroidal anti-inflammatory drug, is a selective cyclooxygenase-1 and cyclooxygenase-2 COX-1 and COX-2 inhibitor, and exhibits anti-inflammatory, analgesic, and antipyretic activities. It is used in muscular, skeletal, and joint disorders such as hydrotrolic and rheumatoid arthritis.
It is also used oslubilization the treatment of other painful conditions including postoperative pain and primary dysmenorrhoea. Lornoxicam is practically insoluble solubliization water but soluble in alkaline solutions. Most of the previous methods employed have used organic solvents or hydrotropes such as sodium lauryl sulphate and urea to increase aqueous solubility of lornoxicam [ 45 ].
This method could preclude the use of costly solvents in analysis. Lornoxicam was a generous gift sample from Life Care Formulations Pvt. All other chemicals and solvents used were of analytical grade. The solutions were filtered yhdrotropic Whatman filter paper No.
From the stock solution, serial dilutions were made solkbilization the absorbances of solutions were measured at the respective wavelength as per the developed method to confirm the solubilizatikn.
In order to check the accuracy and reproducibility of the proposed method, recovery studies were conducted. The solution was then filtered through Whatman filter paper No. Drug content was estimated and percent recovery was calculated using the following formula.
Consider where is the amount of drug found before addition of pure drug, is the amount of drug found after addition of pure drug, and is the amount of pure drug added. Precision was determined by studying the repeatability and intermediate precision.
The standard deviation, coefficient of variance CVand standard error were calculated for the drug. The intraday concentration of the drug was calculated on the same day at an interval of one hour, whereas the interday concentration of drug was calculated on three different days, within solubiliztion laboratory conditions [ 7 ]. Solubiluzation intersubject variation was calculated by taking into account the analysis carried out by three different individuals on the same day and at the same time, within the laboratory conditions [ 89 ].
LOD and LOQ were calculated as andrespectively, where is the slope of the calibration curve and is the standard deviation of response [ 10 ]. The solubility of pure lornoxicam in distilled water was found to be 0. The increase in solubility was more than fold. Hence this method was optimized and employed in the analysis of the tablet formulation.
A portion of the solution was kept at room temperature for 24 hours to check the stability of drug in presence of sodium benzoate.
The study revealed that estimations of lornoxicam can be done within 24 hours without any detrimental effect on drug stability as no solublization was observed.
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Sodium benzoate is cheaper than most of the organic solvents and thus may be a better substitute for expensive organic solvents that are used in routine analysis of pharmaceuticals. The drug showed good regression value at this wavelength. It was evident that there is good correlation between the amounts estimated and the label claim. Accuracy and reproducibility of the proposed method were further confirmed by recovery studies.
The results of the study revealed that any small change in the drug concentration in the solution could be accurately determined by the proposed method Table 2.
Repeatability results indicated the precision under the same operating conditions over a short interval of time and interassay precision. Intermediate precision study expresses variation within laboratory conditions in different days. In intra- and interday precision and intersubject variation study, coefficient of variation was not more than 1.
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The value of LOD was 0. Thus a new method has been developed that is precise, simple, cost effective, accurate, and safe which has been validated.
This proposed method which was developed on the principle of hydrotropic hydroteopic concept can be well employed in routine analysis of lornoxicam in tablets.
The authors are thankful for Gokula Education Foundation for providing necessary facilities to carry out the research work. International Scholarly Research Notices.
Abstract Lornoxicam is a selective cyclooxygenase-1 and cyclooxygenase-2 inhibitor solubilziation exhibits anti-inflammatory, analgesic, and antipyretic activities. Introduction Various techniques have been employed to enhance the aqueous solubility of poorly water-soluble drugs.
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